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"Joe Quadri, owner and operator of CR2000 Collagen lost 43 lbs this past year with the help of the all new CR2000 diet program called The Half Program Diet. An innovative diet program involving all three CR2000 Collagen Type I & III Products: Type I & III Powder, Type I & III Tablets and Type I & III Liquid. To read about Joe's weight loss story and how The Half Program Diet helped Joe achieve his weight loss goal please open the PDF link below. The Half Program Diet (easy to print version)."

Collagen Supplements Science and Nutrition Report
By Sarah Quadri, Bachelor of Science in Biomolecular Science

Introduction

The word “collagen” is derived from kolla, the Greek word for glue. It is the strong fiber that weaves throughout the body for strength and support to literally hold the body together like glue would. Collagen is the most abundant protein in the body with about 14 or so known types.

As we age, the body’s ability to make collagen protein and its different complexes slows down. In time, a collagen deficiency occurs in the skin, joints, and other parts of the body, weakening the connective tissues that holds us together. The remaining collagen fibers may also lose their moist texture and become rigid, mainly due to free radical damage. The combined lack of collagen and dehydrated collagen can manifest itself as wrinkles; joint pain; brittle hair, skin and nails; and other connective tissue conditions.
To replace lost and replenish dried out collagen, external lotions and creams have been popular for years. Collagen injections for wrinkles are also popular. Recently, however, attention has shifted to the use of collagen as an oral supplement.

Oral supplementation of collagen provides a way in which the body can be provided vital amino acids and proteoglycans (specialized sugars in the body) important to maintenance of connective tissues. Currently, two main collagen supplements are being utilized—a combined Collagen Type I & Collagen Type III oral supplement and a Collagen Type II supplement, as these are the most abundant types in the body.

Collagen Type I & Collagen Type III are the chief collagen types in hair, skin, nails, tendons, ligaments, muscles, bones, teeth, eyes, and blood vessels. Although their presence is beneficial in joint tissues, Collagen Type II is the true major component of joint cartilage. Collagen Type II (particularly from chicken sternal cartilage) supplies vital amino acids, hyaluronic acid, chondroitin, and glucosamine for optimal articular (joint) cartilage support.

Collagen Type I & Collagen Type III

Studies have shown that more than 90% of the collagen found in the body is Collagen Type I & Collagen Type III, which are naturally found together as fibril forming or tissue forming collagens.

The protein composition consists of nineteen amino acids responsible for growth, maintenance, and repair of the body, with unusually high proportions of the amino acids glycine and proline, as well as hydroxyproline and hydroxylysine (two amino acids unique to collagen) all found in particularly high concentration in tendons ligaments, bone, organ capsules, skin, fibrous cartilage, blood vessels and fascia.

Collagen Type I provides a great deal of mechanical strength to structures like bones because of its ability to resist tension, while Collagen Type III is involved in the maintenance of expansile organs, wound healing, and tendon and ligament attachments.
Due to the importance of the roles of Collagen Type I & Collagen Type III, it would be logical to provide a supplement which is geared towards providing the building blocks to support collagen in the body, and this is where collagen oral supplementation fits in.
Collagen Type I & Collagen Type III supplements can be made from bovine (beef), porcine (pork), or fish sources. When made from these sources, the product is best utilized when it is hydrolyzed, (broken down into smaller pieces on the molecular level by the addition of enzymes for better absorption.) Bovine skin offers one of the best sources of Collagen Type I & Collagen Type III with the following breakdown of amino acids*:

Alanine 8.5%
Arginine 7.9%
Aspartic Acid 5.70%
Cystine 0.08%
Glutamic Acid 9.50%
Glycine 22.80%
Histidine 0.77%
Hydroxyproline 13.00%
Hydroxylysine 0.70%
Isoleucine 1.30%
Leucine 2.9%
Lysine 4.2%
Methionine 0.78%
Phenylalanine 2.0%
Proline 13.80%
Serine 3.30%
Threonine 1.90%
Tyrosine 0.40%
Valine 2.40%

*represent average grams amino acid per 100 grams, amounts may vary

Note: the high levels of glycine and proline offer ideal building blocks for repair of muscles, tissues, and skin. By supplementing this natural ratio of amino acids, rather than large, random amounts of certain amino acids, an individual can receive more balanced collagen support.

Oral supplementation of Collagen Type I & Collagen Type III can be used not only for aesthetic concerns like hair, skin, and nails, but also to address damage such as a torn meniscus, back muscle problems, and even nutritional support for muscle and collagen diseases like fibromyalgia and Ehlers Danlos syndrome.

In fibromyalgia, a disease involving unexplainable muscle pain, some speculate that some sufferers may have low amounts of Collagen Type III in their bodies, and this may be addressed with supplementation and nutrition. Interestingly enough, Collagen Type III is especially important in that it is the earliest collagen laid down by the body in the connective tissue healing process. In the genetic disease Ehlers Danlos syndrome, individuals lack the chromosomal marker for making collagen and suffer pain as a result. Individuals supplementing their diets with Collagen Type I and Collagen Type III have seen some relief in their symptoms, in particular when using CR2000 Collagen™ brand of Collagen Type I & Collagen Type III (produced by NeoCell Corporation experienced in collagen since 1986 and distributed exclusively in Canada by the CR2000 Collagen™ brand and Cell Renew 2000 Inc.).

*The above statements have not been evaluated by the Food and Drug Administration. These products are not intended to diagnose, cure, or prevent any disease. Results will vary among individuals. Always consult with your physician